Role of S-Adenosylmethionine in Vitamin B12-dependent Methionine Synthesis

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Role of S-adenosylmethionine in methionine biosynthesis in yeast.

Extracts of Saccharomyces cerevisiae were used to develop a cell-free system capable of converting the beta-carbon of serine into the methyl group of methionine. No requirement for either S-adenosylmethionine or S-adenosylhomocysteine could be demonstrated for net methionine biosynthesis. Growth of the cells in B(12) did not affect the reaction. The mechanism for the methylation of homocysteine...

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Further studies on the relationship of vitamin B12 to methionine synthesis in extracts of Escherichia coli.

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ژورنال

عنوان ژورنال: Journal of Biological Chemistry

سال: 1966

ISSN: 0021-9258

DOI: 10.1016/s0021-9258(18)99880-7